Probably erected after the saint’s two visits to the city (1419-1422), it stands at the entrance to Pignolo Street.
Reconsecrated by the bishop in 1593, perhaps after a radical restoration, it was gradually adorned.
Between the 19th and 20th centuries it acquired its present neo-Gothic style.
It has a single hall marked by 5 bays and a gabled facade.
The high altarpiece is by Lorenzo Lotto (1521).
The church is managed by the Parish of St. Alexander in the Cross, which opens it free of charge thanks to the cooperation of volunteers from the Italian Touring Club, since March 5, 2024, it has been temporarily closed for structural inspections.